However, pollution caused by anthropogenic sources is overcome by contamination from natural sources. Vitamin C compound mixtures prevent ozone-induced oxidative damage in human keratinocytes as initial assessment of pollution protection. This review addresses the impact of environmental stressors on skin aging, especially those related to general and specific external factors (lifestyle, occupation, pollutants, and light exposure). Exposure of human skin to benzo[a]pyrene: role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation. The h-index (also known as the Hirsch index or Hirsh index) is a scientometric parameter used to evaluate the scientific impact of the publications and journals. If a similar downward trend continues, In vivo and in vitro studies have shown that short-term exposure to O3 produces ROS, biomolecule oxidation, depletion of cellular antioxidant defenses, cell stress, and cytotoxicity (Valacchi et al., 2002; Valacchi et al., 2015; Krutmann et al., 2017). PM consists of a mixture of components that may be liquid and solid as well as organic and inorganic. The appearance and function of human skin undergo profound changes with increasing chronological age (intrinsic or chronological aging) and with cumulative exposure to external factors (extrinsic aging). 2017 May 8;5(5):CD012657. In contrast, demand issues include just-in-time inventory, higher demand for a product, seasonal demand, and unpredictable demand. ROS induced by pollutants alters lipids, proteins, and DNA. These effects could be amplified by the damaging synergy of the sun, especially UVA rays and pollution. This review addresses the impact of environmental stressors on skin aging, especially those related to general and specific external factors (lifestyle, occupation, pollutants, and light exposure). , Similarly, UVA activated NOX activity decreasing FLG expression (Valencia and Kochevar, 2008). Experimental Pharmacology and Drug Discovery, College of Veterinary Medicine, Zagazig University, in Experimental Pharmacology and Drug Discovery, 2023 Frontiers Media S.A. All rights reserved, Cardiovascular and Smooth Muscle Pharmacology, Gastrointestinal and Hepatic Pharmacology, Integrative and Regenerative Pharmacology, Pharmacology of Ion Channels and Channelopathies. This activation induces homeostatic responses to counteract the damage and systemic (Slominski and Wortsman, 2000; Slominski et al., 2013a; Slominski et al., 2013b; Slominski et al., 2015). Some AhR ligands modulate the regulatory T cells differentiation or increase the proinflammatory differentiation of Th 17. The https:// ensures that you are connecting to the FOIA Photo-pollution stress in skin: traces of pollutants (PAH and particulate matter) impair redox homeostasis in keratinocytes exposed to UVA1. However, this honorarium is based on the total number of submitted articles during a calendar year, and not the number of accepted articles. How Influential is Frontiers in Pharmacology? RORs, reporting odds ratios; MTX, methotrexate; ILD, interstitial lung disease; RA, rheumatoid arthritis; FA, folic acid; TNFi, tumor necrosis factor inhibitor. The deaths per year due to ambient (outdoor) air pollution reached 4.2 million in 2016. Systematic review and meta-analysis of human skin diseases due to particulate matter. Volume 21, Issues 6, 2023. Frontiers in PharmacologySCI "FRONT PHARMACOL" "FRONT PHARMACOL" Other means of exposure to PAH include food and drinking water contaminated by environmental sources. Thus, in 2018, the fourth AhR meeting concluded that the normal physiological AhR continues to present different results due to its highly complex and tissue-specific functions. Xia Q., Chiang H. M., Yin J. J., Chen S., Cai L., Yu H., et al. Hls A., Sugiri D., Fuks K., Krutmann J., Schikowski T. (2018). Meanwhile, electron spin resonance indicated that singlet oxygen and a superoxide radical anion were generated from UVA photoirradiation of B[a]P products in a light-dose responding manner (Xia et al., 2015) ( Real-world PM extracts differentially enhance Th17 differentiation and activate the aryl hydrocarbon receptor (AHR). Wang Y., Gao D., Atencio D. P., Prez E., Saladi R., Moore J., et al. Drug Saf. 2022 Mar 30;19(7):4102. doi: 10.3390/ijerph19074102. The production of ROS in the mitochondria of keratinocytes occurs in the deepest cells of the epidermis, especially in the stem cells at the basal layer; in the final process of differentiation, the keratinocytes stratum corneum lose their organelles. As the skin ages, and due to the imbalance in the production of free radicals, the number of keratinocytes and fibroblasts decreased as a consequent reduction in the turnover of the epidermis and the subsequent decrease in collagen and proteoglycans, respectively. Exposure to extremely high concentrations of dioxin produces, among others, skin lesions in humans as chloracne. The Convention of Stockholm in 2001 identified 12 POPs or the dirty dozen. According to the source, POPs can be grouped into three categories: i) pesticides that, although banned, are still used in some countries, ii) POPs whose origins are from the industry, like polychlorinated biphenyls (PCB), and iii) unintended industrial by-products. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. However, ROS are also produced in the endoplasmic reticulum (ER) being members of the cytochrome P450 family, the main ROS producers. As shown in in vitro and in vivo studies, environmental contaminants such as PAH and TCDD and dioxins produce hyperpigmentation by increasing the enzymes that synthesize melanin via AhR activation (Luecke et al., 2010). Table 3 UVR, mostly UV-B radiation, alters DNA by the formation of pyrimidinepyrimidine dimers (mainly thyminethymine dimers). Only leading researchers acting as Associate Editors, who are not part of Frontiers staff, can make acceptance decisions based on reviews performed by external experts acting as Review Editors or reviewers. Check out our author guidelines for everything you need to know about submission, from choosing a journal and section to preparing your manuscript. 2017 Mar 10;3(3):CD012591. Cyclooxygenase enzymes (COX) convert arachidonic acid into PG, amplifying the recruitment of inflammatory cells. The impact of air pollutants, UV exposure and geographic location on vitamin D deficiency. Figure 1 In the troposphere, it is considered to be a secondary contaminant because it is formed through primary chemical precursor reactions. An official website of the United States government. ROS also induces NF-B activation. Traffic-related air pollution contributes to development of facial lentigines: further epidemiological evidence from Caucasians and Asians. Several studies in vivo and in vitro support the idea that PM induces skin damage by producing oxidative stress and inflammation, and both mechanisms are essential contributors to skin aging ( Published online 2021 Aug 23. . Careers, Unable to load your collection due to an error. (2017). ). -, Fleischmann R., Tongbram V., van Vollenhoven R., Tang D. H., Chung J., Collier D., et al. The chemical name of dioxin is 2,3,7,8-tetrachlorodibenzo (TCDD). In the Independent Review Stage the assigned reviewers perform an in-depth review of the article independently of each other to safeguard complete freedom of opinion. Frontiers in Neuroscience. Research is the product of an investment by society and therefore its fruits should be returned to all people without borders or discrimination, serving society universally and in a transparent fashion. In epidermal KC, AhR activation results from the absorbance of UVB radiation by tryptophan (Trp). The treatment also altered the influx of Ca2+ and cell proliferation, as well as the production of IL-8, TNF-, and IL-1 (Kwon et al., 2018) ( Aging also produces a progressive decrease in skin function, leading to the accumulation of age-related pathologies, such as impaired wound healing (Maru et al., 2014). Prevalence and severity of the skin scars and comedones. Flow chart for determining crude reporting odds ratios (cRORs) and adjusted RORs (aRORs), Calculation of the crude reporting odds ratios (cRORs), 95% confidence intervals (95% CIs),, Adjusted reporting odds ratios (aRORs) (95% CI) for MTX-related adverse events (interstitial lung, MeSH Air pollution, autophagy, and skin aging impact of particulate matter (pm10) on human dermal fibroblasts. ). The average 5-year exposure to UVR has been estimated using NASA satellite data and data from the German Climate Center. Unable to load your collection due to an error, Unable to load your delegates due to an error. The reference values for PM10 are 20 and 50 g/m3, respectively, and 10 and 25 g/m3, respectively, for PM2.5 (World Health Organization, 2014). Montagna W., Kirchner S., Carlisle K. (1989). doi: 10.1002/14651858.CD012437. Perillaldehyde inhibits ahr signaling and activates nrf2 antioxidant pathway in human keratinocytes. Authors are therefore free to disseminate and re-publish their articles, subject to any requirements of third-party copyright owners and subject to the original publication being fully cited. However, transient receptor potential vanilloid 1 TRPV1 is known to be expressed in the epidermis, and it can act as a sensitive transducer (Kwon et al., 2018). Valacchi G., van der Vliet A., Schock B. C., Okamoto T., Obermuller-Jevic U., Cross C. E., et al. The immunological barrier and antimicrobial defense are aspects of great importance in the cutaneous barrier. Several researchers have been made to identify the effects of toxic effect of each component, PAH. Li M., Vierktter A., Schikowski T., Hls A., Ding A., Matsui M. S., et al. 26/06/2023 (2019). Aging increases the likelihood of skin lesions. 10.1002/pds.1742 On the other hand, AhR in the non-canonical pathway also plays a critical role in regulated T cell responses. ). Status Publisher Keeper From To Updated Extent of archive; Preserved. -, Addo S. A., Abdulai M., Yawson A., Baddoo A. N., Zhao J., Workneh N., et al. The coverage history of this journal is as follows: 2010-2022. Pollutants induce the production of NALP3a. But not only ultraviolet radiation produces oxidative stress and aging. official website and that any information you provide is encrypted 10.1331/JAPhA.2013.12218 Dbrowska A. K., Spano F., Derler S., Adlhart C., Spencer N. D., Rossi R. M. (2018). Table 3 It is computed in the year 2022 as per its definition and based on Scopus data. Editors encourage collaboration between clinicians and basic scientists and welcome papers issued from a collaborative strategy between the academic and the private industrial sectors that could assist in the reversal of the current decline in the production of original medicines. Old receptor, new tricks-the ever-expanding universe of aryl hydrocarbon receptor functions. TCDD also induced an increase in the expression of pro-inflammatory cytokines and inflammation markers such as IL1, IL6, IL22, TNF-, and cysteine-rich protein 61 (CCN1) (Rudyak et al., 2018) ( VIS also produces DNA damage indirectly through ROS production (Slominski et al., 2018a). Supply issues consist of manufacturing problems, unavailability of raw materials, logistic problems, and business problems.
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